Background: The incidence of chronic diseases, such as coronary disease, diabetes, overweight, obesity, cancer and other diseases continues to be increasing
August 31, 2020
Background: The incidence of chronic diseases, such as coronary disease, diabetes, overweight, obesity, cancer and other diseases continues to be increasing. function medication, molecular and cellular biology, using the advanced technology of genomics specifically, metabolomics and proteomics, modern medicine offers entered molecular medication, which will make it feasible to supply early caution of persistent diseases. Eradication of pathogenic anti-aging and elements is now a spot in wellness market, that are associated with persistent diseases prevention. Avoidance and treatment of in vivo subjected and residual environmental poisons (weighty metals, pesticides, poisonous chemical substances and microorganisms) (1), denatured and unpredictable proteins (protein broken by residue of weighty metals, pesticides, and other physical, chemical and biological factors), accumulated endogenous metabolites and toxins (increased LDL, uric acid, creatinine, HCY, Free radical, etc.), immunosuppressive factors (immune complex, Autoimmune disease related factors, autoantibody, COX2, etc.), chronic inflammatory factors (TNF-, IL-1, IL-6, IL-8, etc.) and imbalanced gut microbiota have important significance in chronic diseases prevention and risk intervention (2,3). Therefore, we established Target Elimination–denatured and unstable proteins, environmental toxins, metabolic wastes, immunosuppressive factors and chronic inflammatory factor (TE-PEMIC), which is a Cytochalasin H system for the prevention and treatment of chronic diseases. Human environmental toxins exposure and residual can cause cellular damage With the aggravation of environmental pollution, heavy metals enter human body through a variety of ways (1). This not only damages the bodys blood vessels, nerve, immune systems, causes hematopoietic disorder, but also increases diseases incidence (2, 3). Heavy metal pollution is particularly prominent. Build Cytochalasin H up of weighty metals in body relates to persistent illnesses carefully, such as tumor. Categorized arsenic, cadmium, chromium, nickel and other heavy metals are carcinogenic to human (4). Heavy metal exposure can affect human metabolism system, leading to metabolic disorders (5).The contents of heavy metal Lithium and cadmium in blood was significantly related to metabolic syndromes. Heavy metal can be detected in patients with atherosclerosis (6, 7). Environmental risk factors can induce abnormal mitochondrial metabolism in cells to cause cardiac and renal dysfunction, ultimately lead to irreversible pathological changes (8). Long term exposure to low doses of heavy metals may cause diabetes or high blood pressure which cause occurrence and development of cardiovascular diseases (9). Exposure to heavy metals in human body may affect oxidative stress, cell cycle regulation, proliferation, methylation and DNA repair activity (10). Exposure to cadmium may lead to breast cancer, chromium and nickel exposure may increase the risk of pancreatic cancer (11), palladium and RHEB mercury exposure could increase the risk of cancerous goiter (12). Besides, comparative study between population in volcanic area and other areas shows that contents of heavy metals in water resources in the volcanic area is significantly higher than those in other areas which leads to higher incidence of thyroid cancer (13). Prevention and Cytochalasin H control of pathogenic heavy metals have been included in environment planning and remediation all over the world. In recent years, extensive use of insecticides and pesticides has taken many unwanted effects. Research claim that long-term low dosage of pesticides and pesticides residues may damage the function and framework of DNA, induce genetic mutations then, which might induce tumor (1). At the moment, the interaction mechanism of DNA and pesticide has turned into a hot filed in environmental medicine and public health. Pesticides possess cytotoxicity and genotoxicity in human being, animals and vegetation (14). As reported, organic phosphorus pesticide chlorpyrifos can induce apoptosis in human being mononuclear cells. Furthermore to dual and solitary strand breaks due to phosphorus pesticide chlorpyrifos, methyl parathion and malathion harm DNA by DNA-protein cross-linking also. Organic phosphorus pesticides (acephate, methamidophos, chloramine phosphorus, malathion, malaoxon) may damage DNA, boost intracellular ROS and lipid peroxidation item malonaldehyde (MDA), but decrease the activity of superoxide dismutase (SOD), catalase (Kitty), glutathione (GSH). Oxidative tension induced DNA harm. Increasingly more data support how the increasing price of persistent disease could be related to the usage of pesticides. As a total result, intervention of contact with pesticides residues and poisonous chemicals plays an important role in environmental medicine and preventive medicine. Results The metabolic imbalance and accumulation of metabolites Metabolism are chemical reactions during the process of material and energy exchange, which is vital to maintain the organism in a stable structure and.