Low-fat diets have already been shown to increase plasma concentrations of
May 29, 2017
Low-fat diets have already been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) in plasma as well as small dense LDL particles. 0.0001). Diet-induced changes in Lp(a) were strongly correlated with changes in OxPL/apoB (< R1626 0.0001). The increases in plasma Lp(a) levels after the LFHC diet were also correlated with decreases in medium LDL particles (< 0.01) and increases in very small LDL particles (< 0.05). These results demonstrate that induction of increased levels of Lp(a) by an LFHC diet is associated with increases in OxPLs and with changes in LDL subclass distribution that may reflect altered metabolism of Lp(a) particles. < 0.0001) apoB (< 0.05) Lp(a) (< 0.01) OxPL/apoB (< 0.005) and OxPL-apo(a) (< 0.05) were significantly higher with the LFHC diet than with the HFLC diet. In contrast total Rabbit polyclonal to ARL16. cholesterol (= 0.06) LDL cholesterol (< 0.05) HDL cholesterol (< 0.0001) and apoA-1 (< 0.0001) were lower on the LFHC diet. TABLE 2. Subject characteristics TABLE 3. Plasma measurements during high-fat low-carbohydrate (HFLC) and low-fat high-carbohydrate (LFHC) diets R1626 Plasma lipoprotein mass concentrations (mg/dl) and LDL and R1626 Lp(a) peak particle diameters (?) are shown in Table 4. Compared with the HFLC diet large and small VLDL significantly increased on the LFHC diet. Large and medium LDL decreased significantly whereas small and incredibly small LDL improved for the LFHC diet plan weighed against the HFLC diet plan. Needlessly to say the LFHC diet plan reduced suggest LDL maximum particle size from 262 to 257 considerably ?. Nevertheless mean Lp(a) maximum particle diameter didn’t differ between your diets. Desk 4. Plasma lipoprotein mass concentrations (mg/dl) and size (?) during high-fat low-carbohydrate (HFLC) and low-fat high-carbohydrate (LFHC) diet programs Desk 5 demonstrates diet-induced adjustments in Lp(a) had been considerably correlated with adjustments in OxPL/apoB (= 0.49 < 0.0001) and LDL cholesterol (= 0.40 < 0.005). On the other hand there have been no significant organizations between diet-induced adjustments in Lp(a) and plasma triglyceride total cholesterol (= 0.08) HDL cholesterol apoB (= 0.07) and apoA-I. Raises in Lp(a) using the LFHC diet plan were tightly related to to raises in OxPL/apoB R1626 (< 0.0001) (Fig. 1). Multivariate model evaluation showed the organizations between diet-induced adjustments in Lp(a) and adjustments in OxPL/apoB had been independent of adjustments in plasma triglyceride total cholesterol LDL cholesterol HDL cholesterol apoA-I and apoB (data not really demonstrated). Furthermore raises in OxPL/apoB using the LFHC diet plan were positively connected with LDL cholesterol (< 0.01) apoB (< 0.05) and total cholesterol (= R1626 0.06) (data not shown). Fig. 1. Spearman's relationship between diet-induced adjustments in lipoprotein(a) [Lp(a)] (mg/dl) and oxidized phospholipids per apolipoprotein B-100 (OxPL/apoB) n = 62 = 0.49 < 0.0001. RLU comparative light device. TABLE 5. Spearman's correlations between diet-induced adjustments in Lp(a) and lipids lipoproteins and apolipoproteins We discovered a reciprocal romantic relationship between your diet-induced adjustments in moderate and very little LDL (= ?0.46 < 0.0005) and good sized and small LDL (= ?0.31 < 0.05) (data not shown). The diet-induced adjustments in Lp(a) had been favorably correlated to adjustments with moderate LDL (< 0.01) (Desk 5) (Fig. 2) and negatively with adjustments in really small LDL (< 0.05) (Desk 5). Remember that as demonstrated in Desk 4 regardless of the positive relationship between Lp(a) and moderate LDL as well as the upsurge in Lp(a) with LFHC there is a mean decrease in moderate LDL from 102.2 to 88.4 mg/dl with the dietary plan. 15 Furthermore.6% from the variance from the diet-induced changes in Lp(a) was described by changes in medium and incredibly small LDL. Modification for adjustments in degrees of moderate and very little LDL resulted in an increase of the mean change in Lp(a) from 2.17 mg/dl to 2.85 mg/dl. Fig. 2. Spearman's correlation between diet-induced changes in lipoprotein(a) [Lp(a)] (mg/dl) and medium-size LDL II particles (mg/dl). n = 62 = 0.34 < 0.01. The value corresponding to mean changes in Lp(a) and LDL II is shown by ×. Lp(a) peak particle diameter was positively correlated with LDL peak particle diameter during the LFHC diet (< 0.01) but not on the HFLC diet (= 0.12) (data not shown) and diet-induced changes in peak particle diameter of LDL and Lp(a) were not correlated (= 0.97) (Table 4). DISCUSSION The results of this dietary intervention study utilizing a randomized crossover design demonstrate that an LFHC diet increases levels of both Lp(a) and OxPL/apoB and that this response involves a diet-induced increase in OxPL on Lp(a) particles. Furthermore the correlated changes in Lp(a) and.