Tag: LY3009104

Objectives: This study aims to evaluate clinical predictors of nocturia in

Objectives: This study aims to evaluate clinical predictors of nocturia in individuals with obstructive sleep apnea (OSA). (= 0.071). In multivariate analysis age over 70 years and moderate AHI were statistically significant predictors of nocturia (coefficients 0.6 and -0.2 with = 0.003 and 0.03 respectively). Conclusions: This study identifies age and AHI score as predictors of nocturia in individuals with OSA. This may indicate the usefulness of incorporating nocturia in the screening of individuals with OSA. Long term studies are needed to further evaluate mechanism of action medical significance and effect of treatment for nocturia in individuals with OSA. < 0.05. Table 1 Bivariate logistic analyses of OSA variables most likely to contribute to nocturia Table 2 Multivariate logistic regression of age waist circumference STOP questionnaire and apnea hypopnea index RESULTS Median age was 45 years in Group I and 50 years in Group II (= 0.008) having a male to female percentage of 2:1 in both [Table 1]. There were more obese individuals (BMI 30 in Group II but the overall mean BMI of 30 was related between groups. Median systolic and diastolic pressures did not differ between organizations. Median neck circumference was higher among males in both organizations but neck size did not differ between the two organizations when stratified by sex. Waist circumference did not differ significantly (38 40 in . respectively = 0.09). There were no variations in Mallampati uvula size snoring score or oxygen desaturation nadir during sleep screening. Group II with OSA and nocturia experienced LY3009104 significantly higher STOP scores (1.46 1.27 in Group I = 0.005) and a tendency toward higher AHI approached statistical significance (= 0.071). Median nocturia episodes were 2.18 in Group II. In multivariate analysis nocturia was positively expected in individuals over the age of 70 years having a coefficient of 0.6 (= 0.003). Nocturia was found to be negatively expected in individuals having a moderate AHI of 15-29 (coefficient - 0.2 = 0.03). No additional covariates of age STOP score AHI or waist circumference approached significance [Table 2]. DISCUSSION Indeed nocturia is one of the most common reasons for patient LY3009104 referral to urology. Nocturia is definitely a highly common sign particularly in the individuals over 60 years of age.[13 14 15 16 In one northern European study the prevalence of nocturia inside a Danish cohort of individuals reached LY3009104 up to 77%.[15] Likewise epidemiological prevalence studies possess generally indicated that nocturia Rabbit Polyclonal to GCNT7. increase with ageing.[16 17 Nocturia is traditionally defined as storage-phase dysfunction that eventually prospects to LUTS. The underlying etiology of nocturia is definitely potentially caused by reduced nocturnal bladder capacity and a large urine volume produced during the night and/or sleep problems.[15 19 Despite variable pathogenesis nocturia is primarily caused by underlying BPH.[15] Moreover nocturia can symbolize possible contribution of systemic disease; renal endocrine neurological LY3009104 or cardiovascular malfunction making treatment challenging. Medications such as diuretics selective serotonin re-uptake inhibitors (SSRIs) calcium channel blockers tetracycline and lithium can also result in improved diuresis.[14 16 The multivariate analysis reported herein identifies two risk factors for nocturia inside a human population with OSA. Held only age is definitely a well-known positive risk element for nocturia. In our study age over 70 years held up as such even when controlling for additional covariates. Interestingly moderate AHI of 15-29 showed negative predictive value which LY3009104 means that individuals with this category were less likely to have nocturia. From what is known both anecdotally and based on pathophysiologic mechanisms AHI would be expected LY3009104 to positively correlate with nocturia. That is to say the higher the AHI the higher the likelihood of having nocturia. The combined counterintuitive results demonstrating moderate AHI as a negative predictor for nocturia could symbolize several things. Nocturia may be a multi-factorial component of some individuals OSA disease process but not necessarily a surrogate for OSA severity. The most likely explanation is definitely that additional.