Emerging data suggest that several measurable biomarkers in blood vessels might
May 9, 2017
Emerging data suggest that several measurable biomarkers in blood vessels might provide a book window in to the pathophysiology of stroke. remains to be to become validated quantitatively. Larger clinical studies are warranted to determine the awareness and specificity of biomarkers for regular use in scientific heart stroke. GLOSSARY BBB = blood-brain hurdle; BNP = mind natriuretic peptide; CRP = C-reactive protein; GFAP = glial fibrillary acidic protein; HT = hemorrhagic transformation; ICH = intracerebral hemorrhage; Is definitely = ischemic stroke; MMP-9 = matrix metalloproteinase-9; NDKA = nucleoside diphosphate kinase A; NMDA-R = Author disclosures are provided at the end of the article. Received October 30 2008 Approved in final form May 1 2009 Recommendations 1 Adams HP Jr. del Zoppo G Alberts MJ et al. Recommendations for the early management of adults with ischemic stroke. Stroke 2007;38:1655-1711. [PubMed] 2 Chalela JA Kidwell CS Nentwich LM et al. Magnetic resonance imaging and computed tomography in emergency assessment of individuals with suspected acute stroke: a prospective assessment. Lancet 2007;369:293-298. [PMC free article] [PubMed] 3 Hand PJ Kwan J Lindley RI Dennis MS Wardlaw JM. Distinguishing between stroke and WYE-132 mimic in the bedside: the brain attack study. Stroke 2006;37:769-775. [PubMed] 4 Donnan GA Davis SM. Neuroimaging the ischaemic penumbra and selection of individuals for acute stroke therapy. Lancet Neurol 2002;1:417-425. [PubMed] 5 Castellanos M Serena J. Applicability of biomarkers in ischemic stroke. Cerebrovasc Dis 2007;24 suppl 1:7-15. [PubMed] 6 Whiteley W Tseng MC Sandercock P. Blood biomarkers in the analysis of ischemic stroke: a systematic review. Stroke 2008;39:2902-2909. [PubMed] 7 Dambinova SA Khounteev GA Izykenova GA Zavolokov IG Ilyukhina AY Skoromets AA. Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of individuals with transient ischemic assault and stroke. Clin Chem 2003;49:1752-1762. [PubMed] Rabbit Polyclonal to MARK3. 8 Reynolds MA Kirchick HJ Dahlen JR et al. Early biomarkers of stroke. Clin Chem 2003;49:1733-1739. [PubMed] 9 Lynch JR Blessing R White colored WD Grocott HP Newman MF Laskowitz DT. Novel diagnostic test for acute stroke. Stroke 2004;35:57-63. [PubMed] 10 Laskowitz DT Blessing WYE-132 R Floyd J White colored WD Lynch JR. Panel of biomarkers predicts stroke. Ann NY Acad Sci 2005;1053:30. [PubMed] 11 Laskowitz DT Kasner SE Saver J Remmel KS Jauch EC. Clinical usefulness of a biomarker-based diagnostic test WYE-132 for acute stroke: the Biomarker Quick Assessment in Ischemic Injury (Mind) study. Stroke 2009;40:77-85. [PubMed] 12 Saenz AJ Lee-Lewandrowski E Solid wood MJ et al. Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon joggers before and after the 2005 Boston marathon. Am J Clin WYE-132 Pathol 2006;126:185-189. [PubMed] 13 Baird AE. Blood genomics in human being stroke. Stroke 2007;38:694-698. [PubMed] 14 Moore DF Li H Jeffries N et al. Using peripheral blood mononuclear cells to determine a gene manifestation profile of acute ischemic stroke: a pilot investigation. Blood circulation 2005;111:212-221. [PubMed] 15 Tang Y Xu H Du X et al. Gene manifestation in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab 2006;26:1089-1102. [PubMed] 16 Xu H Tang Y Liu DZ et al. Gene manifestation in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab 2008;28:1320-1328. [PubMed] 17 Meisel C Schwab JM Prass K Meisel A Dirnagl U. Central nervous system injury-induced immune deficiency symptoms. Nat Rev Neurosci 2005;6:775-786. [PubMed] 18 Laterza OF Modur VR Crimmins DL et al. Id of book human brain biomarkers. Clin Chem 2006;52:1713-1721. [PubMed] 19 Allard L Burkhard PR Lescuyer P et al. Recreation area7 and nucleoside diphosphate kinase A as plasma markers for the first diagnosis of heart stroke. Clin Chem 2005;51:2043-2051. [PubMed] 20 Han MH Hwang SI Roy DB et al. Proteomic evaluation of energetic multiple sclerosis lesions reveals healing targets. Character 2008;451:1076-1081. [PubMed] 21 Ning MM Wang X Lo EH. Reperfusion damage after heart stroke: neurovascular proteases as well as the blood-brain.